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KMID : 0356420070250030089
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Journal of Korean Andrology
2007 Volume.25 No. 3 p.89 ~ p.96
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Stem Cell Therapy for Erectile Dysfunction
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Song Yun-Seob
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Abstract
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Although the introduction of oral phosphodiesterase-5 inhibitors has revolutionized the treatment of erectile dysfunction, here is still a need for new effective therapies for patients who fail to respond or who have severe cardiovascular disease. tem cell therapy may restore physiological erections following normal endogenous signals. Treatments based on stem ells have the advantages of no inflammation and less immune rejection. Immunohistochemical evidence for nerve reservation and improved erectile function in rats after administration of neural embryonic stem cells intracavernosally has een reported. Potential differentiation of mesenchymal stem cells to endothelial cells and smooth muscle cells after injection into the corpus cavernosum in rats was confirmed. Mesenchymal stem cells alone or mesenchymal stem cells ltered by gene therapy with endothelial nitric oxide synthase or calcitonin-related peptide restored damaged rectile physiology and improved erectile capacity in rats. Injection of skeletal muscle-derived cells into the corpus cavernosum improved erectile function. Fetal and cord blood stem cells also can be used as the source of stem cells. Recently, multipotent amniotic fluid-derived stem cells have been isolated. Advances in the research of amniotic fluid-derived stem ells are expected to further raise the hope for stem cell therapy. Stem cell therapy to restore erectile function may present a fascinating new therapeutic strategy for future treatment.
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KEYWORD
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Penis, Erectile dysfunction, Stem cell
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